Journal: International Journal of Molecular Sciences
Article Title: FBXL7 Body Hypomethylation Is Frequent in Tumors from the Digestive and Respiratory Tracts and Is Associated with Risk-Factor Exposure
doi: 10.3390/ijms23147801
Figure Lengend Snippet: Gene body methylation is correlated with FBXL7 expression in UADT tumors. Correlation analysis between FBXL7 methylation (all Illumina HumanMethylation450 BeadChip (Illumina, San Diego, CA, USA) probes available) and mRNA expression levels in esophageal (ESCC), larynx (LSCC), oral cavity (OCSCC) and oropharynx squamous cell carcinoma (OPSCC) from TCGA datasets. The black arrow indicates the probe that is validated by pyrosequencing in the present study.
Article Snippet: The Gene Expression Omnibus (GEO) database was assessed to retrieve the DNA methylation data (Illumina HumanMethylation450 BeadChip methylation microarray platform) from the OPSCC (GSE38271), esophageal adenocarcinoma (GSE72874), lung adenocarcinoma (GSE56044), lung squamous cell carcinoma (GSE68825), cervical carcinoma (GSE99511), nasopharyngeal carcinoma (GSE62336) and colorectal adenocarcinoma (GSE101764) datasets.
Techniques: Methylation, Expressing